The urethra is a hollow tube that leads from the bladder, through the prostate gland, and through the penis to open at the tip of the glans. It carries urine to the outside of the body to empty the bladder. The vas deferens lead sperm from the testicles into the urethra during ejaculation. In addition, there are glands called the seminal vesicles that empty fluid into the urethra during ejaculation. The ejaculate, called semen, contains a mixture of sperm and secretions from the vas deferens, the seminal vesicles, and the prostate. Pre-ejaculate, the small amount of fluid released before ejaculation, may contain sperm and cause pregnancy, and it may transmit infection as well. The urethra should not burn or itch, and normally there should not be any discharge from it. The urethra can become infected with bacteria (such as those that cause gonorrhea, chlamydia, and nongonoccal urethritis), viruses (herpes, genital warts), and protozoa (trichomoniasis) through sexual contact.

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